P822 The negative impact of mental health comorbidity in children and young adults with inflammatory bowel disease: a UK population-based cohort study

Abstract Background Whilst the high burden of mental health comorbidity in people with inflammatory bowel disease (IBD) is now being recognised, less known about additional impacts having concurrent IBD and a condition, especially children young adults. Methods We conducted retrospective, observational study using large UK primary care dataset (Optimum Patient Care Research Database). Children adults (aged 5-25 years) diagnosed prior to 2015 were identified grouped into those without prevalent conditions (any depression, anxiety, eating disorders, body image disorder, attention-deficit behavioural adjustment acute stress schizophrenia, bipolar disorder or post-traumatic disorder). The following outcomes compared over 5 years two groups; quality-of-life indicators (bowel symptoms [abdominal pain, discomfort bloating, diarrhoea], systemic [fatigue, sleep problems, weight-loss, underweight, growth retardation], emotional function [low mood, substance abuse, deliberate self-harm, suicidal attempt parasuicide] social [absence from school, absence work, unemployment]), IBD-specific therapy interventions (diet [nutritional supplements], medications [oral rectal 5-aminosalicylic acid steroids, antimetabolites tumour necrosis factor inhibitors] surgery stoma formation]), healthcare utilisation (primary interactions hospital admissions). Adjustment for confounders was performed Cox regression non-recurring (e.g. formation), negative binomial Poisson recurring events interactions). Results 1,943 individuals identified. 295 these had condition. Mental associated increased (adjusted Incident Rate Ratio [aIRR] 1.82; 95% Confidence Interval [CI] 1.33, 2.52), disturbance Hazard [aHR] 1.63; CI 1.02, 2.62), abuse (aHR 3.63; 1.69, 7.78), (aIRR 1.33; 1.12, 1.58) admissions 1.87; 1.29, 2.75) (Figure 1). In >18 old, time off work 1.55; 1.21, 1.99) Conclusion symptoms, work. Given impact comorbidity, it crucial affected are monitored receive appropriate support as part their multidisciplinary care.